Screen Summary

Gallipoli P (2018) - 1-PMID29463564

Title: Glutaminolysis is a metabolic dependency in FLT3 acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

Screen Details:

Notes:
  • Authors screened MOLM13 cells treated with the highly potent and specific FLT3ITD inhibitor AC220 (quizartinib) for genes which resulted in synthetic lethality to identify genes and pathways that would sensitize FLT3ITD AML to FLT3-TKI treatment

Score Distribution

< -0.643674486
> -3.603478037

CRISPR Screen Results (302 hits)