CRISPR Screen Dataset
Shalem O (2014) - 3-PMID24336571
Title: Genome-scale CRISPR-Cas9 knockout screening in human cells.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Melanoma Cell Line [BTO:0000849]
- Cell Line : A-375 [BTO:0002806, CELLOSAURUS:CVCL_0132]
- Phenotype : Response To Chemicals
- Condition : Vemurafenib (2.0 µM) [ChEBI]
- Library : GECKO | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RIGER | Number of Hits: 100 | Full Dataset Size: 18,080
- Experimental Setup : Drug Exposure | Duration: 14 Days | MOI: = 0.3
- Significance : Authors have indicated that ALL results are to be considered significant.
Notes:
- Phenotypic readout: cell proliferation
Score Distribution
< 0.04346
> 0.0007519