CRISPR Screen Dataset
Krall EB (2017) - 1-PMID28145866
Title: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Lung Cancer Cell Line [BTO:0000762, EFO:0002934]
- Cell Line : HCC364 [EFO:0006420, CELLOSAURUS:CVCL_5134]
- Phenotype : Response To Chemicals
- Condition : Trametinib (24 nM) [ChEBI]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 40 | Full Dataset Size: 20,506
- Experimental Setup : Drug Exposure | Duration: 21 Days
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.1 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Phenotypic readout: cell proliferation
Score Distribution
< 20.71724504
> 0.301032231