CRISPR Screen Dataset
Bakke J (2019) - 1-PMID30898113
Title: Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.
Screen Details:
- Screen Rationale : Increased drug sensitivity
- Cell Type : Pancreatic Cancer Cell Line [BTO:0000794]
- Cell Line : PANC-1 [BTO:0000304, CELLOSAURUS:CVCL_0480]
- Phenotype : Response To Chemicals
- Condition : Gemcitabine (100.0 nM) [ChEBI]
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 1,073 | Full Dataset Size: 19,114
- Experimental Setup : Drug Exposure | Duration: 6 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Phenotypic readout: cell proliferation
Score Distribution
< 0.99996
> 0.00000247