CRISPR Screen Dataset

Name: CRISPR SCREEN: Sack LM (2018) - 2-PMID29576454 (Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.)
Creator: BioGRID Project

Sack LM (2018) - 2-PMID29576454

H. sapiens

Title: Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Screen Details:

Screen Rationale : Growth-promoting genes and oncogenes
Cell Type : Mammary Epithelial Cell Line [BTO:0002768]
Cell Line : HMEC
Phenotype : Cell Proliferation
Library : Human Activity-optimized genome-wide library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 823 | Full Dataset Size: 18,162
Experimental Setup : Timecourse | Duration: 11 Doublings | MOI: = 0.2
Significance : Authors have indicated that results with Score.1 (p-Value) < 0.3 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

CRISPR GO genes (growth-promoting genes and oncogenes) have a Mageck adjusted p < 0.3 for depletion.

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 1

> 0.002475

CRISPR Screen Results (823 hits)

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