CRISPR Screen Dataset

Name: CRISPR SCREEN: Sack LM (2018) - 1-PMID29576454 (Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.)
Creator: BioGRID Project

Sack LM (2018) - 1-PMID29576454

H. sapiens

Title: Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Screen Details:

Screen Rationale : Suppressors of tumorigenesis or proliferation (mammary epithelial cell)
Screen Type : Positive Selection | Format: Pool
Cell Line : HMEC | Type: Mammary Epithelial Cell Line
Throughput : High Throughput
Enzyme : CAS9
Phenotype : Viability
Experimental Setup : Timecourse | Duration: 11 Doublings | MOI: = 0.2
Library : Human Activity-optimized genome-wide library | Type: CRISPRn | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 143 | Full Dataset Size: 18,162
Significance : Authors have indicated that results with Score.1 (p-Value) < 0.3 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

CRISPR STOP genes (suppressors of tumorigenesis or proliferation) have a Mageck adjusted p < 0.3 for enrichment.

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 1

> 0.000309

CRISPR Screen Results (143 hits)

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