Screen Summary
Sack LM (2018) - 1-PMID29576454
Title: Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.
Screen Details:
- Screen Type : Positive Selection | Format: Pool
- Cell Line : HMEC | Type: Mammary Epithelial Cell Line
- Throughput : High Throughput
- Enzyme : CAS9
- Phenotype : Viability
- Experimental Setup : Timecourse | Duration: 11 Doublings | MOI: = 0.2
- Library : Activity-optimized genome-wide library | Type: CRISPRn | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 143 | Full Dataset Size: 18,162
- Significance : Authors have indicated that results with Score.1 (p-Value) < 0.3 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- CRISPR STOP genes (suppressors of tumorigenesis or proliferation) have a Mageck adjusted p < 0.3 for enrichment.
Score Distribution
< 1
> 0.000309