CRISPR Screen Dataset

Name: CRISPR SCREEN: Gilbert LA (2014) - 3-PMID25307932 (Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.)
Creator: BioGRID Project

Gilbert LA (2014) - 3-PMID25307932

H. sapiens

Title: Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Screen Details:

Screen Rationale : Gene activation decreases fitness
Cell Type : Chronic Myeloid Leukemia Cell Line [BTO:0002580]
Cell Line : K-562 [BTO:0000664, CELLOSAURUS:CVCL_0004]
Phenotype : Cell Proliferation
Library : CRISPRa (Weissman, 2014) [AddGene] | Type: CRISPRa | Format: Pool | Enzyme: sunCas9 | Methodology: Activation
Analysis Method : Log2 Fold Change (L2FC) | Number of Hits: 142 | Full Dataset Size: 15,977
Experimental Setup : Timecourse | Duration: 10 Days | MOI: < 1
Significance : Authors have indicated that results with Score.1 (Gamma (normalized log2e/t)) <= -0.1 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

activation of hit genes results in decreased fitness

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 0.190915104

> -0.523663585

CRISPR Screen Results (142 hits)

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