CRISPR Screen Dataset
Brunen D (2018) - 1-PMID29440296
Title: PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Neuroblastoma Cell Line [BTO:0000932, EFO:0005214]
- Cell Line : Kelly [EFO:0002069, CELLOSAURUS:CVCL_2092]
- Phenotype : Response To Chemicals
- Condition : AZD-1208 (2 μmol/L) [ChEMBL]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : DESeq | Number of Hits: 28 | Full Dataset Size: 19,050
- Experimental Setup : Drug Exposure | Duration: 30 Days
- Significance : Authors have indicated that ALL results are to be considered significant.
Notes:
- Phenotypic readout: cell proliferation
Score Distribution
< 8.63
> 5