CRISPR Screen Dataset
Tzelepis K (2016) - 8-PMID27760321
Title: A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Embryonic Stem Cell Line [BTO:0001581]
- Cell Line : JM8.F6 [CELLOSAURUS:CVCL_J961]
- Phenotype : Cell Proliferation
- Library : Murine lentiviral gRNA library (version 1) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 360 | Full Dataset Size: 19,149
- Experimental Setup : Timecourse | Duration: 14 Days
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.1 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Depleted genes were identified at a cutoff of FDR 10% (FDR < 0.1).
Score Distribution
< 1
> 0.000000000314