CRISPR Screen Dataset
Tzelepis K (2016) - 4-PMID27760321
Title: A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
- Cell Line : MOLM-13 [BTO:0004175, CELLOSAURUS:CVCL_2119]
- Phenotype : Cell Proliferation
- Library : Human Improved Genome-wide Knockout CRISPR Library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 1,359 | Full Dataset Size: 18,009
- Experimental Setup : Timecourse | Duration: 25 Days
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.2 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Depleted genes were identified at a cutoff of FDR 20% (FDR < 0.2).
Score Distribution
< 1
> 0.000000000269