CRISPR Screen Dataset
Reddy A (2017) - 3-PMID28985567
Title: Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.
Screen Details:
- Screen Rationale : Cell-essential genes and growth restrictive genes
- Cell Type : Lymphoblastoid Cell Line [EFO:0005292]
- Cell Line : Pfeiffer [EFO:0006472, CELLOSAURUS:CVCL_3326]
- Phenotype : Cell Proliferation
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Mann-Whitney U test | Number of Hits: 432 | Full Dataset Size: 18,862
- Experimental Setup : Timecourse | Duration: 14 Doublings | MOI: ~ 0.4
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- The authors screened lymphoma cell lines and determined which genes are significantly enriched or depleted after 14 doublings.
Score Distribution
< 2.248
> -3.73