CRISPR Screen Dataset
Reddy A (2017) - 2-PMID28985567
Title: Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.
Screen Details:
- Screen Type : Negative Selection | Format: Pool
- Cell Line : SU-DHL-4 | Type: Lymphoma Or Leukaemia Cell Line
- Throughput : High Throughput
- Enzyme : CAS9
- Phenotype : Viability
- Experimental Setup : Timecourse | Duration: 14 Doublings | MOI: ~ 0.4
- Library : GECKO v2 | Type: CRISPRn | Methodology: Knockout
- Analysis Method : Mann-Whitney U test | Number of Hits: 1,376 | Full Dataset Size: 18,862
- Significance : Authors have indicated that results with Score.1 (CRISPR Score (CS)) < 0 AND Score.2 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- The authors screened lymphoma cell lines and determined which genes are significantly depleted after 14 doublings.
Score Distribution
< 2.203
> -6.5