Screen Summary

Pan D (2018) - 3-PMID29301958

Title: A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.

Screen Details:

Notes:
  • The authors screened for gene knockouts in a melanoma cell line that conferred increased sensitivity to killing by cytotoxic OT-I T cells, which have a high TCR affinity for an endogenous melanoma antigen

Score Distribution

< -1.38
> -3.63

CRISPR Screen Results (152 hits)