Screen Summary

Pan D (2018) - 1-PMID29301958

Title: A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.

Screen Details:

Notes:
  • The authors screened for gene knockouts in a melanoma cell line that conferred increased sensitivity to killing by cytotoxic Pmel-1 T cells, which have a relatively low TCR affinity for an endogenous melanoma antigen

Score Distribution

< 0.49
> -3.93

CRISPR Screen Results (252 hits)