CRISPR Screen Dataset
Cheng J (2017) - 1-PMID29028833
Title: Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Cancer Cell Line [EFO:0001639]
- Cell Line : MKL-1 [CELLOSAURUS:CVCL_2600]
- Phenotype : Cell Proliferation
- Library : Liu Human CRISPR Knockout Library (CRISPRn H1 H2, H1/H2) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 481 | Full Dataset Size: 18,460
- Experimental Setup : Timecourse | Duration: 1 Months | MOI: = 0.3
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- MKL-1 cells are a Merkel cell carcinoma (MCC) cell line that contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST)
Score Distribution
< 0.99998
> 0.00000000000499