CRISPR Screen Dataset

Cheng J (2017) - 1-PMID29028833

Title: Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.

Screen Details:

  • Screen Rationale : Cell-essential genes
  • Cell Type : Cancer Cell Line [EFO:0001639]
  • Cell Line : MKL-1
  • Phenotype : Cell Proliferation
  • Library : H1/H2 library | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
  • Analysis Method : MaGeCK | Number of Hits: 481 | Full Dataset Size: 18,460
  • Experimental Setup : Timecourse | Duration: 1 Months | MOI: = 0.3
  • Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.
Notes:
  • MKL-1 cells are a Merkel cell carcinoma (MCC) cell line that contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST)

Score Distribution

< 0.99998
> 0.00000000000499

CRISPR Screen Results (481 hits)