CRISPR Screen Dataset
Patel UA (2025) - 2-PMID40899441
Title: CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer.
Screen Details:
- Screen Rationale : Decreased resistance to radiation
- Cell Type : Thoracic SMARCA4-deficient Undifferentiated Tumor
- Cell Line : SBC-5 [CELLOSAURUS: CVCL_1679]
- Phenotype : Cell Viability [CMPO:0000013]
- Condition : Radiation
- Library : Epi-Drug Library | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : DrugZ | Number of Hits: 45 | Full Dataset Size: 1,054
- Experimental Setup : Radiation Exposure | Duration: 25 Days
- Significance : Authors have indicated that results with Score.4 (FDR) < 0.1 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- A low-throughput CRISPR screen was carried out to identify potential targets for radiosensitization in small cell lung cancer (SCLC).
Score Distribution
< 3.43
> -6.47