CRISPR Screen Dataset
Soriaga LB (2025) - 6-PMID40372436
Title: Shared host genetic landscape of respiratory viral infection.
Screen Details:
- Screen Rationale : Increased/decreased resistance to virus
- Cell Type : Lung Cancer Cell Line [BTO:0000762, EFO:0002934]
- Cell Line : A-549 [BTO:0000018, CELLOSAURUS:CVCL_0023]
- Phenotype : Response To Virus
- Condition : Virus: Human parainfluenza 3 virus [NCBI Taxid 11217]
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 43 | Full Dataset Size: 20,193
- Experimental Setup : Virus Exposure | Duration: 36 Hours
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.05 OR Score.4 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a significant positive score upon KO suggests the gene normally plays a pro-viral role
- Genes with a significant negative score upon KO suggests the gene normally plays an anti-viral role
Score Distribution
< 0.99999
> 1.1541e-17