CRISPR Screen Dataset
Soriaga LB (2025) - 4-PMID40372436
Title: Shared host genetic landscape of respiratory viral infection.
Screen Details:
- Screen Rationale : Increased/decreased resistance to virus
- Cell Type : Cervical Adenocarcinoma Cell Line [BTO:0005590]
- Cell Line : HEp-2 [CELLOSAURUS:CVCL_1906, BTO:0000976]
- Phenotype : Response To Virus
- Condition : Virus: Respiratory syncytial virus strain A2 (15.0 MOI) [NCBI Taxid 11259]
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 100 | Full Dataset Size: 20,187
- Experimental Setup : Virus Exposure | Duration: 48 Hours
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.05 OR Score.4 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a significant positive score upon KO suggests the gene normally plays a pro-viral role
- Genes with a significant negative score upon KO suggests the gene normally plays an anti-viral role
Score Distribution
< 0.99989
> 0.0000000000000067371