CRISPR Screen Dataset

Name: CRISPR SCREEN: Morgens DW (2017) - 4-PMID28474669 (Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens.)
Creator: BioGRID Project

Morgens DW (2017) - 4-PMID28474669

H. sapiens

Title: Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens.

Screen Details:

Screen Type : Positive Selection | Format: Pool
Cell Line : K-562 cell | Type: Chronic Myeloid Leukemia Cell Line
Throughput : High Throughput
Enzyme : CAS9
Phenotype : Toxin Resistance
Experimental Setup : Toxin Exposure | Duration: 14 Days | Condition Name: Ricin (0.25 ng/mL)
Library : Bassik Human CRISPR Knockout Library | Type: CRISPRn | Methodology: Knockout
Analysis Method : CasTLE | Number of Hits: 895 | Full Dataset Size: 20,440
Significance : Authors used a complex method to determine significant results. Please refer to the source publication for more details. Significant results are indicated by 'Yes' in the HIT column of the table below.

Notes:

authors used a cut-off of FDR<= 10% to determine significance

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 526

> 0

CRISPR Screen Results (895 hits)

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