CRISPR Screen Dataset
Panea RI (2019) - 2-PMID31558468
Title: The whole-genome landscape of Burkitt lymphoma subtypes.
Screen Details:
- Screen Rationale : Cell-essential and growth restrictive genes
- Cell Type : Burkitt Lymphoma Cell Line [BTO:0000889]
- Cell Line : BL-41 [BTO:0003854, CELLOSAURUS:CVCL_1087, DEPMAP:ACH-000245]
- Phenotype : Cell Proliferation
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Differential CRISPR score | Number of Hits: 1,332 | Full Dataset Size: 19,050
- Experimental Setup : Timecourse | Duration: 3 Weeks
- Significance : Authors have indicated that results with Score.1 (CRISPR Score (CS)) < -1.0 AND Score.2 (FDR) < 0.05 OR Score.1 (CRISPR Score (CS)) > 1.0 AND Score.2 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Significantly depleted genes (negative CRSIPR score) are essential genes in the BL-41 cell line, their KO results in decreased growth
- Significantly enriched genes (positive CRSIPR score) are growth restrictive genes in the BL-41 cell line, their KO results in increased growth
Score Distribution
< 1.458401781
> -4.130541266