Screen Summary

Meyers RM (2017) - 56-PMID29083409

Title: Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

Screen Details:

Notes:
  • To identify gene hits at an FDR < 0.05, ORCS estimated FDRs for the CERES Avana dataset using customized gold-standard positive and negative sets of genes. The custom positive set included genes essential in at least 90% of cell lines in both the CERES Avana dataset (PMID:29083409) and the 10 lines included in Bertomeu et al. (PMID:29038160). The custom negative set included genes essential in zero cell lines from one of the two datasets and in <=10% of the other dataset.

Score Distribution

< 1.99211830442
> -1.58253307861

CRISPR Screen Results (2155 hits)