CRISPR Screen Dataset

Name: CRISPR SCREEN: Kwanten B (2023) - 6-PMID36731340 (E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.)
Creator: BioGRID Project

Kwanten B (2023) - 6-PMID36731340

H. sapiens

Title: E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.

Screen Details:

Screen Rationale : Increased/decreased drug resistance
Cell Type : Lymphoma Or Leukaemia Cell Line [EFO:0002937]
Cell Line : KMS-28BM [CELLOSAURUS:CVCL_2994, EFO:0006617]
Phenotype : Response To Chemicals
Condition : selinexor (40.0 nM) [ChEBI]
Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : CRISPRBetaBinomial | Number of Hits: 230 | Full Dataset Size: 19,115
Experimental Setup : Drug Exposure | Duration: 28 Days | MOI: ~ 0.25
Significance : Authors have indicated that results with Score.2 (p-Value) < 0.01 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

Hit genes with a positive lfc show increased resistance to selinexor
Hit genes with a negative lfc show increased sensitivity to selinexor

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 1.101041891

> -1.305171523

CRISPR Screen Results (230 hits)

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