CRISPR Screen Dataset
Gaidt MM (2021) - 1-PMID34759314
Title: Self-guarding of MORC3 enables virulence factor-triggered immunity.
Screen Details:
- Screen Rationale : Regulation of IFN response
- Cell Type : Lymphoma Or Leukaemia Cell Line [EFO:0002937]
- Cell Line : BLaER1 [CELLOSAURUS:CVCL_VQ57, EFO:0030018]
- Phenotype : Protein/peptide Distribution [APO:0000209]
- Library : Bassik Human CRISPR Knockout Library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Robust-rank aggregation (RRA) | Number of Hits: 13 | Full Dataset Size: 20,467
- Experimental Setup : Timecourse | Duration: 3 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.001 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- The authors screened for genes that negatively regulate IFN using Viperin accumulation as a readout
Score Distribution
< 1
> 0.00000000966