CRISPR Screen Dataset
Sohail M (2021) - 1-PMID34316707
Title: A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.
Screen Details:
- Screen Rationale : Increased/decreased drug resistance
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Response To Chemicals
- Condition : GPS167 (813.0 nM) [PubChem]
- Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RANKS | Number of Hits: 21 | Full Dataset Size: 18,688
- Experimental Setup : Drug Exposure | Duration: 8 Days
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes with a negative RANKS score show increased sensitivity to GPS167 upon KO
- Hit genes with a positive RANKS score show increased resistance to GPS167 upon KO
Score Distribution
< 3.15
> -3.94