CRISPR Screen Dataset
Wang T (2014) - 2-PMID24336569
Title: Genetic screens in human cells using the CRISPR-Cas9 system.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
- Cell Line : HL-60 [BTO:0000738, CELLOSAURUS:CVCL_0002]
- Phenotype : Response To Chemicals
- Condition : Etoposide (200.0 nM) [ChEBI]
- Library : Human CRISPR Knockout Pooled Libraries (Enriched Sub-pools) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Kolmogorov-Smirnov | Number of Hits: 3 | Full Dataset Size: 7,114
- Experimental Setup : Drug Exposure | Duration: 12 Days
- Significance : Authors have indicated that results with Score.1 (Log10 (Corrected p-Value)) > 1.3 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Phenotypic readout: cell proliferation
- The threshold used to determine significant genes is -log10(corrected p-value)>1.3
Score Distribution
< 4.423
> 0