CRISPR Screen Dataset
Benslimane Y (2021) - 2-PMID33660365
Title: A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Screen Details:
- Screen Rationale : Cell essential and growth restrictive genes in a TAPR1 (HAPSTR1) KO background
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Cell Proliferation
- Condition : Mutation: HAPSTR1 (TAPR1) (ETG29035) KO
- Library : Toronto Knockout version 3 (TKOv3) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : DrugZ | Number of Hits: 378 | Full Dataset Size: 18,055
- Experimental Setup : Timecourse | Duration: 15 Days | MOI: = 0.5
- Significance : Authors have indicated that results with Score.1 (Z-score) < -4.1 OR Score.1 (Z-score) > 3.55 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a negative GI score show a synthetic lethal interaction with TAPR1 KO
- Genes with a positive GI score show a buffering interaction with TAPR1 KO
Score Distribution
< 6.43
> -9.2