CRISPR Screen Dataset
Hayes TK (2019) - 3-PMID30819666
Title: A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma.
Screen Details:
- Screen Rationale : Increased resistance to drug
- Cell Type : Melanoma Cell Line [BTO:0000849]
- Cell Line : Mel JuSo [BTO:0001588, CELLOSAURUS:CVCL_1403]
- Phenotype : Response To Chemicals
- Condition : Trametinib|Palbociclib [ChEBI, ChemSpider]
- Library : Avana | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 72 | Full Dataset Size: 18,335
- Experimental Setup : Drug Exposure | Duration: 21 Days
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of the hit genes results in increased resistance to a trametinib/palbociclib combination therapy
Score Distribution
< 5.840451859
> 0.83456498