CRISPR Screen Dataset

Bandopadhayay P (2019) - 3-PMID31160565

H. sapiens

Title: Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Screen Rationale : Cell-essential genes
Cell Type : Medulloblastoma Cell Line [BTO:0001359]
Cell Line : D341 Med [EFO:0002157, CELLOSAURUS:CVCL_0018]
Phenotype : Cell Proliferation
Library : Avana | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : CERES | Number of Hits: 1,703 | Full Dataset Size: 17,673
Experimental Setup : Timecourse | Duration: 21 Days | MOI: ~ 0.5
Significance : Authors have indicated that results with Score.1 (Dependency score) > 0.35 AND Score.2 (FDR) < 0.2 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

< 1

> 0