CRISPR Screen Dataset
Jiang C (2022) - 1-PMID35192680
Title: Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Response To Chemicals
- Condition : panobinostat (10.0 nM) [ChEBI]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 681 | Full Dataset Size: 20,916
- Experimental Setup : Drug Exposure | Duration: 7 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of the hit genes confers resistance to panobinostat
Score Distribution
< 1
> 0.0000000795