CRISPR Screen Dataset

Name: CRISPR SCREEN: Khan DH (2020) - 1-PMID32299104 (Mitochondrial carrier homolog 2 is necessary for AML survival.)
Creator: BioGRID Project

Khan DH (2020) - 1-PMID32299104

H. sapiens

Title: Mitochondrial carrier homolog 2 is necessary for AML survival.

Screen Details:

Screen Rationale : Cell-essential genes
Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
Cell Line : OCI-AML-2 [BTO:0004619, CELLOSAURUS:CVCL_1619]
Phenotype : Cell Proliferation
Library : TKO (Toronto Knockout) v1 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 147 | Full Dataset Size: 17,237
Experimental Setup : Timecourse | Duration: 14 Days
Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

Authors screened a genome-wide library for genes whose KO resulted in decreased proliferation in acute myeloid leukemia but only published results for the mitochondrial subset they were focused on

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 0.99956

> 0.00000000439

CRISPR Screen Results (147 hits)

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