CRISPR Screen Dataset
Griffin GK (2021) - 1-PMID33953401
Title: Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Screen Details:
- Screen Rationale : Tumor cell response to immune checkpoint blockade
- Cell Type : Lung Cancer Cell Line [BTO:0000762, EFO:0002934]
- Cell Line : LL/2 (LLC1) [BTO:0000745, CELLOSAURUS:CVCL_4358]
- Phenotype : Tumorigenicity
- Condition : PD-1/CTLA-4 blockade
- Library : CRISPRn Targeted Chromatin Regulator Library (Bernstein, 2021) | Type: CRISPRn | Format: in vivo | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 155 | Full Dataset Size: 1,057
- Experimental Setup : Implantation to Mouse Model | Duration: 15 Days
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Authors triggered immune checkpoint blockade (ICB) by combination PD-1/CTLA-4 blockade and looked for genes whose KO sensitized (decreased proliferation) of tumor cells in response to ICB.
Score Distribution
< 10.76022749
> 0.002804624