CRISPR Screen Dataset
Lin KH (2019) - 2-PMID30773463
Title: Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
- Cell Line : MOLM-13 [BTO:0004175, CELLOSAURUS:CVCL_2119]
- Phenotype : Response To Chemicals
- Condition : Venetoclax [ChEBI]
- Library : CRISPRn Metabolically Focused Library (Wood, 2019) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Log2 (TS) | Number of Hits: 352 | Full Dataset Size: 2,325
- Experimental Setup : Drug Exposure | Duration: 4 Weeks | MOI: = 0.2
- Significance : Authors have indicated that results with Score.1 (Gene-level Three Score (TS)) < -0.914 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 0.397474048
> -3.951003278