CRISPR Screen Dataset
Mei H (2021) - 4-PMID34686207
Title: Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist.
Screen Details:
- Screen Rationale : Increased resistance to virus
- Cell Type : HeLa [BTO:0000567, CELLOSAURUS:CVCL_0030]
- Cell Line : H1HeLa [CLO:0003586, CELLOSAURUS:CVCL_3334]
- Phenotype : Response To Virus
- Condition : Virus: Rhinovirus serotype B14 (RV-B14) (1 MOI) [NCBI Taxid 12131]
- Library : Surfaceome Library | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 17 | Full Dataset Size: 2,344
- Experimental Setup : Virus Exposure | Duration: 48 Hours | MOI: = 0.3
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.001 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of hit genes results in increased resistance to rhinovirus
Score Distribution
< 1
> 3.11e-17