CRISPR Screen Dataset

Name: CRISPR SCREEN: Mei H (2021) - 3-PMID34686207 (Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist.)
Creator: BioGRID Project

Mei H (2021) - 3-PMID34686207

H. sapiens

Title: Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist.

Screen Details:

Screen Rationale : Increased resistance to virus
Cell Type : HeLa [BTO:0000567, CELLOSAURUS:CVCL_0030]
Cell Line : H1HeLa [CLO:0003586, CELLOSAURUS:CVCL_3334]
Phenotype : Response To Virus
Condition : Virus: Rhinovirus serotype B14 (RV-B14) (1 MOI) [NCBI Taxid 12131]
Library : CRISPRn (Liu, 2021) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 45 | Full Dataset Size: 18,754
Experimental Setup : Virus Exposure | Duration: 48 Hours | MOI: = 0.3
Significance : Authors have indicated that results with Score.2 (FDR) < 0.001 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

KO of hit genes results in increased resistance to rhinovirus

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 1

> 0.0000000000251

CRISPR Screen Results (45 hits)

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