Screen Summary
Pusapati GV (2017) - 2-PMID29290584
Title: CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Screen Details:
- Screen Type : Phenotype Screen | Format: Pool
- Cell Line : NIH-3T3 cell | Type: Embryonic Fibroblast Cell Line
- Throughput : High Throughput
- Enzyme : CAS9
- Phenotype : Regulation Of Signal Transduction Phenotype
- Experimental Setup : Timecourse | Duration: 24 Hours | MOI: = 0.3
- Library : Brie (mouse) | Type: CRISPRn | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 3,053 | Full Dataset Size: 19,674
- Significance : Authors have indicated that results with Score.1 (p-Value) < 0.1 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Screen for negative regulators of the Hedgehog signaling pathway
Score Distribution
< 0.99998
> 0.000000239