CRISPR Screen Dataset
Hill S (2019) - 4-PMID31868589
Title: Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.
Screen Details:
- Screen Rationale : Cell-essential genes in a CDC34 (UBE2R1)/UBE2R2 mutant background
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Cell Proliferation
- Condition : Mutation: CDC34 (ETG997)/UBE2R2 (ETG54926) Double KO
- Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RANKS | Full Dataset Size: 19,033
- Experimental Setup : Timecourse | Duration: 14 Days | MOI: = 0.36
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 3.39
> -2.96