CRISPR Screen Dataset
Barghout SH (2021) - 2-PMID33476303
Title: A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
- Cell Line : OCI-AML-2 [BTO:0004619, CELLOSAURUS:CVCL_1619]
- Phenotype : Response To Chemicals
- Condition : TAK-243 (30 nM) [PubChem]
- Library : TKO (Toronto Knockout) v1 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 11 | Full Dataset Size: 17,237
- Experimental Setup : Drug Exposure | Duration: 32 Days | MOI: ~ 0.4
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.2 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of the hit genes confers improved growth in the presence of TAK-243
Score Distribution
< 1
> 1.03e-19