CRISPR Screen Dataset
Bertomeu T (2017) - 1-PMID29038160
Title: A high resolution genome-wide CRISPR/Cas9 viability screen reveals structural features and contextual diversity of the human cell-essential proteome.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Cell Proliferation
- Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RANKS | Number of Hits: 2,236 | Full Dataset Size: 18,907
- Experimental Setup : Timecourse | Duration: 15 Days | MOI: = 0.5
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a corrected RANKS score and an FDR < 0.05 were considered significant and essential in the NALM6 cell line.
Score Distribution
< -0.09
> -5.42