CRISPR Screen Dataset

Name: CRISPR SCREEN: Karakus U (2019) - 1-PMID30787439 (MHC class II proteins mediate cross-species entry of bat influenza viruses.)
Creator: BioGRID Project

Karakus U (2019) - 1-PMID30787439

H. sapiens

Title: MHC class II proteins mediate cross-species entry of bat influenza viruses.

Screen Details:

Screen Rationale : Increased resistance to virus
Cell Type : Glioblastoma Cell Line [BTO:0001530]
Cell Line : U-87MG ATCC [BTO:0002036, CELLOSAURUS:CVCL_0022]
Phenotype : Response To Virus
Condition : Virus: VSV-H18 (10 MOI)
Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 19 | Full Dataset Size: 19,114
Experimental Setup : Virus Exposure | Duration: 27 Days | MOI: = 0.3
Significance : Authors have indicated that results with Score.3 (FDR) < 0.01 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

KO of hit genes results in increased resistance to a VSV-H18, which expresses a bat IAV (Influenza A virus) haemagglutinin protein

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 0.99999

> 0.0000000000326

CRISPR Screen Results (19 hits)

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