CRISPR Screen Dataset
Wang T (2015) - 2-PMID26472758
Title: Identification and characterization of essential genes in the human genome.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Chronic Myeloid Leukemia Cell Line [BTO:0002580]
- Cell Line : K-562 [BTO:0000664, CELLOSAURUS:CVCL_0004]
- Phenotype : Cell Proliferation
- Library : Human Activity-optimized genome-wide library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Kolmogorov-Smirnov | Number of Hits: 1,660 | Full Dataset Size: 18,166
- Experimental Setup : Timecourse | Duration: 14 Doublings
- Significance : Authors have indicated that results with Score.1 (CRISPR Score (CS)) < -0.1 AND Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a CRISPR Score (CS) < -0.1 and corrected p-value < 0.05 are considered significant.
Score Distribution
< 1.674
> -5.784