CRISPR Screen Dataset
Loo CS (2020) - 1-PMID32640256
Title: A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function.
Screen Details:
- Screen Rationale : Negative regulators of Foxp3
- Cell Type : Regulatory T Cell [CL:0000815]
- Cell Line : primary Treg
- Phenotype : Protein/peptide Accumulation [APO:0000149]
- Library : Brie (mouse) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 490 | Full Dataset Size: 19,668
- Experimental Setup : Timecourse | Duration: 6 Days | MOI: < 0.2
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.01 AND Score.3 (Log2FC) < -0.5 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 1
> 0.00000000218