CRISPR Screen Dataset
Zhan T (2020) - 1-PMID33186476
Title: Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155.
Screen Details:
- Screen Rationale : Increased/decreased drug resistance
- Cell Type : Colorectal Cancer Cell Line [BTO:0001616]
- Cell Line : HCT 116 [BTO:0001109, CELLOSAURUS:CVCL_0291]
- Phenotype : Response To Chemicals
- Condition : YM-155 (sepantronium bromide) (4 nM) [ChEBI]
- Library : TKO (Toronto Knockout) v1 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 18 | Full Dataset Size: 17,153
- Experimental Setup : Drug Exposure | Duration: 12 Days
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.2 OR Score.4 (FDR) < 0.2 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Authors screened a particular molecular subtype of colorectal cancer for increased resistance (positive score FDR<0.2) or decreased resistance (negative score FDR<0.2) to the BIRC5 suppressor YM155
Score Distribution
< 1
> 0.0000015434