CRISPR Screen Dataset
Nechiporuk T (2019) - 1-PMID31048320
Title: The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
- Cell Line : MOLM-13 [BTO:0004175, CELLOSAURUS:CVCL_2119]
- Phenotype : Response To Chemicals
- Condition : Venetoclax (1.0 μmol/L) [ChEBI]
- Library : Human Improved Genome-wide Knockout CRISPR Library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 877 | Full Dataset Size: 18,007
- Experimental Setup : Drug Exposure | Duration: 7 Days
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of the hit genes confers resistance to venetoclax
Score Distribution
< 1
> 0.0000055