CRISPR Screen Dataset
Tsui CK (2019) - 1-PMID31451760
Title: CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity.
Screen Details:
- Screen Rationale : Regulators of ADC toxicity
- Cell Type : Burkitt Lymphoma Cell Line [BTO:0000889]
- Cell Line : Ramos [BTO:0003079, CELLOSAURUS:CVCL_0597, DEPMAP:ACH-001636]
- Phenotype : Response To Chemicals
- Condition : anti-CD22-asparagine-PEG2-maytansine (2 nM)
- Library : Bassik Human CRISPR Knockout Library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : CasTLE | Number of Hits: 171 | Full Dataset Size: 20,453
- Experimental Setup : Drug Exposure | Duration: 14 Days | MOI: ~ 0.4
- Significance : Authors used a complex method to determine significant results. Please refer to the source publication for more details. Significant results are indicated by '' in the HIT column of the table below.
Score Distribution
< 519
> 0