CRISPR Screen Dataset
Cai MY (2020) - 3-PMID32075772
Title: Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Large Cell Lung Cancer Cell Line [BTO:0002205]
- Cell Line : NCI-H460 [BTO:0002207, CELLOSAURUS:CVCL_0459]
- Phenotype : Response To Chemicals
- Condition : M3541 (ATM inhibitor) (1.0 µM)
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 19 | Full Dataset Size: 19,114
- Experimental Setup : Drug Exposure | Duration: 19 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.1 (STARS Score) >= 4.0 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of hit genes results in increased proliferation in the presence of the drug
Score Distribution
< 10.82739325
> 1.313782591