CRISPR Screen Dataset

Schinzel RT (2019) - 1-PMID31761535

H. sapiens

Title: The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPR.

Screen Rationale : Response to ER stress
Cell Type : Fibroblast Cell Line [BTO:0000453]
Cell Line : BJ [BTO:0003807, CELLOSAURUS:CVCL_3653]
Phenotype : Response To Chemicals
Condition : Tunicamycin (200.0 ng/mL) [ChEBI]
Library : Avana | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : Log2 Fold Change (L2FC) | Number of Hits: 2,798 | Full Dataset Size: 18,623
Experimental Setup : Drug Exposure | Duration: 21 Days | MOI: ~ 0.4
Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 OR Score.4 (p-Value) < 0.05 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

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