CRISPR Screen Dataset
Krall EB (2017) - 4-PMID28145866
Title: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Lung Cancer Cell Line [BTO:0000762, EFO:0002934]
- Cell Line : NCI-H1299 [BTO:0002552]
- Phenotype : Response To Chemicals
- Condition : Trametinib (1.5 µM) [ChEBI]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 10 | Full Dataset Size: 20,703
- Experimental Setup : Drug Exposure | Duration: 21 Days
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.1 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Phenotypic readout: cell proliferation
Score Distribution
< 12.4993174
> 0.30107916