CRISPR Screen Dataset

Name: CRISPR SCREEN: Krall EB (2017) - 3-PMID28145866 (KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.)
Creator: BioGRID Project

Krall EB (2017) - 3-PMID28145866

H. sapiens

Title: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.

Screen Details:

Screen Type : Positive Selection | Format: Pool
Cell Line : CALU1 cell | Type: Lung Cancer Cell Line (BTO)
Throughput : High Throughput
Enzyme : CAS9
Phenotype : Resistance To Chemicals
Experimental Setup : Drug Exposure | Duration: 21 Days | Condition Name: Trametinib (50 nM)
Library : GECKO v2 | Type: CRISPRn | Methodology: Knockout
Analysis Method : STARS | Number of Hits: 84 | Full Dataset Size: 20,307
Significance : Authors have indicated that results with Score.3 (FDR) < 0.1 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

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Score Distribution

< 21.11314763

> 0.301188084

CRISPR Screen Results (84 hits)

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