BioGRID 3.0 - The Next Generation of the Biological General Repository for Interaction Datasets

The BioGRID was updated today to our newest major release designated BioGRID 3.0. To correspond with this release, we’ve updated our interaction data to version 3.0.64 reflecting all interaction data curated prior to April 23rd, 2010. This new release provides many enhancements over the previous BioGRID 2.0 web interface including…

  • A brand new standardized search result interface. Our new interface provides faster results and easier methods of quickly viewing BioGRID interaction data including a summary and table view. You can learn more about the various aspects of the new interface by visiting our search results layout breakdown.
  • Improved search accuracy. When you perform a search, the BioGRID now searches more than 11 million aliases, external database identifiers, and sequence ids to provide an accurate list of results. Results are ordered to provide the most relevant hits first and you can optionally perform a wildcard search or restrict yourself to a specific organism to help fine tune your list. To see a full listing of our supported identifier types, click here.
  • Speed and performance enhancements. BioGRID 3.0 has had many back-end improvements to speed up our entire site to ensure results return quickly and accurately.
  • Customized download generation. In addition to our usual gene and publication specific downloads, you can now build your own dataset to include multiple genes or publications in a single file. Visit our custom dataset download generator or our download page to get any dataset you need for your project.
  • Support for greater detail on curated interactions.  In addition to our standard curated interaction data, such as experimental evidence code and publication, BioGRID 3.0 now provides Phenotypes, Throughput (High or Low), Curator Qualification Notes, Quantitative Scores, and Post-Translational Modification (if applicable). If any of this information is available for a curated interaction, it will be displayed on all result pages.
  • Brand new download formats. To accommodate new annotation such as phenotypes and throughput, we’ve created a brand new tab format (named BioGRID Tab 2.0) that provides many additional details over our old format. In addition, we’ve also added support for standardized PSI-MI Tab formatted downloads. To see a full list of our supported download formats, visit our BioGRID download format details page.
  • On-the-fly filtering of search results. On any BioGRID results page (like this one), you now have the option of customizing how your results are displayed using on-the-fly filtering. Simply click on the button directly below the heading “Search Filters” to choose from a list of existing filters. Once activated, associations matching your filter will be weighted poorly and show up at the bottom of all search results and will be colored in gray. This makes it easier for you to skip them and focus on the others. In future versions of the BioGRID, this feature will be greatly expanded to allow for user customized filters that can be saved and re-loaded on subsequent visits as well as filters that can be applied to downloads as well.
  • Improved statistics. On each and every BioGRID search result page (like this one) we’ve improved our statistics providing a more comprehensive breakdown of interactions with data separated into experimental system type (physical or genetic) and throughput (high or low). We’ve also created a new statistics page with a breakdown of interactions in the current BioGRID build and all previous builds.
  • Better documentation. The BioGRID website now provides a comprehensive help wiki that provides links to many articles on how best to take advantage of our data. This documentation is just the beginning and will continue to grow and evolve over time.

These are just some of the many improvements now available in BioGRID 3.0. We have many additional features being developed already for version 3.1 that will expand on this functionality and ensure the BioGRID remains a powerful resource for the biological community. If you have any questions about this build, please feel free to contact us at

April 24th, 2010 - 11:49 PM