BioGRID Build 4.2.192 includes 21,405 Coronavirus-related Interactions

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 221 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 21,405 and 47 post-translational modifications including 19,524 interactions and 47 post-translational modifications from 127 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 14 coronavirus-related CRISPR screens.

Specifically, this update features several promising new pre-publications including:

  • Tang X (2020) - A study showing Transferrin receptor (TfR) is an alternative receptor to ACE2 for SARS-CoV-2 and drugs targeting TfR that may prevent and/or treat COVID-19
  • Ichimura T (2020) - A study showing KIM-1/TIM-1 as alternative receptors to ACE2 for SARS-CoV-2 and drugs targeting KIM-1 that may prevent and/or treat COVID-19.
  • Gao C (2020) - A study showing the Spike Protein interacts with Multiple Innate Immune Receptors MR/CD206, DC-SIGN/CD209, L-SIGN/CD209L, and MGL/CLEC10A/CD301

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at

December 1st, 2020 - 01:24 PM